Suppression of apoptosis by pseudorabies virus Us3 protein kinase through the activation of PI3-K/Akt and NF-κB pathways.

@article{Chang2013SuppressionOA,
  title={Suppression of apoptosis by pseudorabies virus Us3 protein kinase through the activation of PI3-K/Akt and NF-κB pathways.},
  author={C Chang and P Lin and Ming-Huei Liao and C I Chang and J Hsu and F Yu and Hung-Yi Wu and W Y Shih},
  journal={Research in veterinary science},
  year={2013},
  volume={95 2},
  pages={
          764-74
        }
}
The pseudorabies virus (PRV) is a major viral disease that causes huge economic loss in the pig industry globally. Most viruses have been found to generate anti-apoptotic factors that facilitate cell survival in the early stages of infection. This study aimed to investigate the anti-apoptotic effects of PRV and study the underlying mechanisms in the early stage of infection. We investigated and compared whether the two PRV Us3 isoforms, Us3a and Us3b, could block apoptosis induced by virus… CONTINUE READING
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