Suppression of apoptosis and granulocyte colony-stimulating factor-induced differentiation by an oncogenic form of Cbl.

@article{Sinha2001SuppressionOA,
  title={Suppression of apoptosis and granulocyte colony-stimulating factor-induced differentiation by an oncogenic form of Cbl.},
  author={Srish Sinha and Jarmila Jancarik and Vera Y Roginskaya and Kristi Rothermund and Linda M. Boxer and Seth J Corey},
  journal={Experimental hematology},
  year={2001},
  volume={29 6},
  pages={746-55}
}
OBJECTIVE The retroviral oncogene v-Cbl causes pre-B cell lymphomas and myeloid leukemias in mice, and its Drosophila homologue is oncogenic, causing enhanced receptor tyrosine kinase signaling. The human Cbl gene resides at 11q23. The aim of this study is to determine the effect of oncogenic Cbl on growth-regulating responses. MATERIALS AND METHODS The oncogenic mutant of Cbl (CblDelta1-357) was transfected into factor-dependent 32Dcl3 myeloid cells. Consequently, cell survival and… CONTINUE READING