Suppression of antiviral innate immunity by sunitinib enhances oncolytic virotherapy.

  title={Suppression of antiviral innate immunity by sunitinib enhances oncolytic virotherapy.},
  author={Babal Kant Jha and Beihua Dong and Carvell T. Nguyen and Irina Polyakova and Robert H. Silverman},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  volume={21 9},
The use of lytic viruses to preferentially infect and eliminate cancer cells while sparing normal cells is a promising experimental therapeutic approach for treating cancer. However, the efficacy of oncolytic virotherapy is often limited by two innate immunity pathways, the protein kinase PKR and the 2'-5'-oligoadenylate (OAS)/RNase L systems, which are widely present in many but not all tumor cell types. Previously, we reported that the anticancer drug, sunitinib, an inhibitor of VEGF-R and… CONTINUE READING
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