Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy.

  title={Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy.},
  author={Koji Otani and I M Nita and William Macaulay and Helga I. Georgescu and P. David Robbins and Christopher H. Evans},
  journal={Journal of immunology},
  volume={156 9},
Gene therapy offers a novel approach to treating human joint diseases such as rheumatoid arthritis. In the present study, we have used the retrovirus, MFG-IRAP, to transfer the human IL-1 receptor antagonist protein (IRAP) gene to rabbits' knees and have assessed its impact on inflammatory and chondrodestructive aspects of the acute phase of antigen-induced arthritis in these joints. Surprisingly, intra-articular expression of IRAP was three- to fivefold higher in arthritic knees than in… CONTINUE READING

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