Suppression of anoikis by SKP2 amplification and overexpression promotes metastasis of esophageal squamous cell carcinoma.

@article{Wang2009SuppressionOA,
  title={Suppression of anoikis by SKP2 amplification and overexpression promotes metastasis of esophageal squamous cell carcinoma.},
  author={Xiaochun Wang and Yu-peng Wu and Beifa Ye and D Lin and Yan-bin Feng and Zi-qiang Zhang and Xin Xu and Yunsheng Han and Y Cai and Jin-Tang Dong and Qimin Zhan and Min Wu and Ming-rong Wang},
  journal={Molecular cancer research : MCR},
  year={2009},
  volume={7 1},
  pages={
          12-22
        }
}
The gene of SKP2, located on chromosome 5p13, plays a critical role in cell cycle progression, especially at the G(1)-S transition, putatively through its control of several cell cycle regulator proteins including p27(kip1), p21(cip1), p57(kip2), p130, cyclin E, and c-Myc. Previous studies in this laboratory revealed that gain of chromosome 5p was often seen in esophageal squamous cell carcinoma (ESCC). In the present study, we examined the amplification status and expression level of SKP2 in… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 21 CITATIONS

Similar Papers

Loading similar papers…