Suppression of angiogenesis, tumorigenicity, and metastasis by human prostate cancer cells engineered to produce interferon-beta.

@article{Dong1999SuppressionOA,
  title={Suppression of angiogenesis, tumorigenicity, and metastasis by human prostate cancer cells engineered to produce interferon-beta.},
  author={Zejun Dong and Graham Greene and Curtis A. Pettaway and Colin P. N. Dinney and Ines Eue and Weiqin Lu and Corazon D. Bucana and Mevlana Derya Balbay and Diane Renee Bielenberg and Isaiah Josh Fidler},
  journal={Cancer research},
  year={1999},
  volume={59 4},
  pages={872-9}
}
We determined whether the IFN-beta gene can be used to suppress angiogenesis, tumor growth, and metastasis of human prostate cancer cells growing in the prostate of nude mice. Highly metastatic PC-3M human prostate cancer cells were engineered to constitutively produce murine IFN-beta subsequent to infection with a retroviral vector containing murine IFN-beta cDNA. Parental (PC-3M-P), control vector-transduced (PC-3M-Neo), and IFN-beta-transduced (PC-3M-IFN-beta) cells were injected into the… CONTINUE READING