Suppression of allergic airway inflammation in a mouse model of asthma by exogenous mesenchymal stem cells.

@article{OuYang2011SuppressionOA,
  title={Suppression of allergic airway inflammation in a mouse model of asthma by exogenous mesenchymal stem cells.},
  author={Hai-Feng Ou-Yang and Yun Huang and Xing-bin Hu and Chang-Gui Wu},
  journal={Experimental biology and medicine},
  year={2011},
  volume={236 12},
  pages={1461-7}
}
Mesenchymal stem cells (MSCs) have significant immunomodulatory effects in the development of acute lung inflammation and fibrosis. However, it is still unclear as to whether MSCs could attenuate allergic airway inflammation in a mouse model of asthma. We firstly investigated whether exogenous MSCs can relocate to lung tissues in asthmatic mice and analyzed the chemotactic mechanism. Then, we evaluated the in vivo immunomodulatory effect of exogenous MSCs in asthma. MSCs (2 × 10(6)) were… CONTINUE READING