Suppression of allergen-specific IgE in offspring after preconceptional immunisation: maternal, paternal and genetic influences.

@article{Nygaard2013SuppressionOA,
  title={Suppression of allergen-specific IgE in offspring after preconceptional immunisation: maternal, paternal and genetic influences.},
  author={Unni Cecilie Nygaard and Jitka Stilund Hansen and E-C Groeng and Ingrid Melkild and Martinus L\ovik},
  journal={Scandinavian journal of immunology},
  year={2013},
  volume={77 2},
  pages={92-103}
}
Immunisation of female mice with the allergen ovalbumin (OVA) during pregnancy reduces the OVA-specific IgE response in adult offspring. To approach primary prevention strategies for allergy, we investigated to what extent genetic, paternal and maternal factors influence this suppressive effect on allergic sensitisation in offspring and investigated the possibility of pregestational immunisation. Maternal allergen immunisation reduced OVA-specific IgE levels in immunised offspring, even after… CONTINUE READING