Suppression of aldosterone by cyproheptadine in idiopathic aldosteronism.

  title={Suppression of aldosterone by cyproheptadine in idiopathic aldosteronism.},
  author={Milton D. Gross and Roger J. Grekin and T C Gniadek and J Z Villareal},
  journal={The New England journal of medicine},
  volume={305 4},
To study the role of serotonin in regulating the release of aldosterone, we gave single, oral doses of cyproheptadine, an antiserotoninergic agent, to five normal volunteers with high aldosterone levels secondary to sodium deprivation and to 14 patients with aldosteronism (six with idiopathic aldosteronism due to bilateral adrenal hyperplasia and eight with adrenal adenoma). A diet containing 150 mmol of sodium was given to the patients with spontaneous aldosteronism, and one containing 10 mmol… CONTINUE READING


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