Suppression of alcohol self-administration and reinstatement of alcohol seeking by melanin-concentrating hormone receptor 1 (MCH1-R) antagonism in Wistar rats

@article{Cippitelli2010SuppressionOA,
  title={Suppression of alcohol self-administration and reinstatement of alcohol seeking by melanin-concentrating hormone receptor 1 (MCH1-R) antagonism in Wistar rats},
  author={Andrea Cippitelli and Camilla Karlsson and Janice L. Shaw and Annika Thorsell and Donald R. Gehlert and Markus Heilig},
  journal={Psychopharmacology},
  year={2010},
  volume={211},
  pages={367-375}
}
Melanin-concentrating hormone (MCH) is involved in regulation of appetitive behaviors as well as emotional reactivity and reward, behavioral domains relevant to alcohol addiction. We evaluated the effects of the non-peptide MCH1 receptor antagonist, GW803430 [6-(4-chloro-phenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-3H-thieno[3,2-d]pyrimidin-4-one; 3–30 mg/kg, i.p.] on alcohol-related behaviors in Wistar rats. Ex vivo binding experiments demonstrated that the GW803430 dose range… CONTINUE READING

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