Suppression of alcohol-induced hypertension by dexamethasone.

  title={Suppression of alcohol-induced hypertension by dexamethasone.},
  author={D Randin and Peter Vollenweider and Luc Tappy and Eric J{\'e}quier and Pascal Nicod and Urs Scherrer},
  journal={The New England journal of medicine},
  volume={332 26},
BACKGROUND Alcohol consumption is associated with an increased incidence of hypertension and stroke, but the triggering mechanisms are unclear. In animals, alcohol causes activation of the sympathetic nervous system and also stimulates the release of corticotropin-releasing hormone (CRH), which has sympatho-excitatory effects when administered centrally. METHODS To determine whether alcohol evokes sympathetic activation and whether such activation is attenuated by the inhibition of CRH… CONTINUE READING