Suppression of aging in mice by the hormone Klotho.

  title={Suppression of aging in mice by the hormone Klotho.},
  author={Hiroshi Kurosu and Masaya Yamamoto and Jeremy D. Clark and Johanne V. Pastor and Animesh Nandi and Prem Gurnani and Owen P. McGuinness and Hirotaka Chikuda and Masayuki Yamaguchi and Hiroshi Kawaguchi and Iichiro Shimomura and Yoshiharu Takayama and Joachim Herz and C Ronald Kahn and Kevin P. Rosenblatt and Makoto Kuro-O},
  volume={309 5742},
A defect in Klotho gene expression in mice accelerates the degeneration of multiple age-sensitive traits. Here, we show that overexpression of Klotho in mice extends life span. Klotho protein functions as a circulating hormone that binds to a cell-surface receptor and represses intracellular signals of insulin and insulin-like growth factor 1 (IGF1), an evolutionarily conserved mechanism for extending life span. Alleviation of aging-like phenotypes in Klotho-deficient mice was observed by… CONTINUE READING
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