Suppression of age-related inflammatory NF-kappaB activation by cinnamaldehyde.

  title={Suppression of age-related inflammatory NF-kappaB activation by cinnamaldehyde.},
  author={Dae Hyun Kim and Chul Hong Kim and M Kim and Ji Young Kim and Kyung Jin Jung and Jae Heun Chung and Won G An and Jae Won Lee and Byung Pal Yu and Hae Young Chung},
  volume={8 5},
Redox sensitive, pro-inflammatory nuclear transcription factor NF-kappaB plays a key role in both inflammation and aging processes. In a redox state disrupted by oxidative stress, pro-inflammatory genes are upregulated by the activation of NF-kappaB through diverse kinases. Thus, the search and characterization of new substances that modulate NF-kappaB are of recent research interest. Cinnamaldehyde (CNA) is the major component of cinnamon bark oil, which has been widely used as a flavoring… CONTINUE READING
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