Suppression of adipocyte hypertrophy by polymethoxyflavonoids isolated from Kaempferia parviflora.

  title={Suppression of adipocyte hypertrophy by polymethoxyflavonoids isolated from Kaempferia parviflora.},
  author={Y. Okabe and T. Shimada and Takumi Horikawa and K. Kinoshita and K. Koyama and K. Ichinose and M. Aburada and K. Takahashi},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  volume={21 6},
  • Y. Okabe, T. Shimada, +5 authors K. Takahashi
  • Published 2014
  • Biology, Medicine
  • Phytomedicine : international journal of phytotherapy and phytopharmacology
  • We previously demonstrated that ethyl acetate extracts of Kaempferia parviflora Wall. Ex Baker (KPE) improve insulin resistance in TSOD mice and showed that its components induce differentiation and adipogenesis in 3T3-L1 preadipocytes. The present study was undertaken to examine whether KPE and its isolated twelve components suppress further lipid accumulation in 3T3-L1 mature adipocytes. KPE reduced intracellular triglycerides in mature adipocytes, as did two of its components, 3,5,7,3',4… CONTINUE READING
    31 Citations
    Effects of ethyl acetate extract of Kaempferia parviflora on brown adipose tissue
    • 12
    Efficacy of Kaempferia parviflora in a mouse model of obesity-induced dermatopathy
    • 5


    Polymethoxyflavonoids from Kaempferia parviflora induce adipogenesis on 3T3-L1 preadipocytes by regulating transcription factors at an early stage of differentiation.
    • 29
    • PDF
    Regulation of adipocytokine secretion and adipocyte hypertrophy by polymethoxyflavonoids, nobiletin and tangeretin.
    • 67
    Nobiletin enhances differentiation and lipolysis of 3T3-L1 adipocytes.
    • 83
    Preventive effect of Kaempferia parviflora ethyl acetate extract and its major components polymethoxyflavonoid on metabolic diseases.
    • 39
    Effects of Sinensetin on Lipid Metabolism in Mature 3T3‐L1 Adipocytes
    • 18
    Antiobesity effects of Kaempferia parviflora in spontaneously obese type II diabetic mice
    • 63
    The ethanolic extract of Kaempferia parviflora reduces ischaemic injury in rat isolated hearts.
    • 29
    Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity.
    • 249
    Anticholinesterase activity of 7‐methoxyflavones isolated from Kaempferia parviflora
    • 74