Suppression of adipocyte differentiation by aldo-keto reductase 1B3 acting as prostaglandin F2alpha synthase.

@article{Fujimori2010SuppressionOA,
  title={Suppression of adipocyte differentiation by aldo-keto reductase 1B3 acting as prostaglandin F2alpha synthase.},
  author={Ko Fujimori and Toshiyuki Ueno and Nanae Nagata and Kaori Kashiwagi and Kosuke Aritake and Fumio Amano and Yoshihiro Urade},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 12},
  pages={
          8880-6
        }
}
Prostaglandin (PG) F(2alpha) suppresses adipocyte differentiation by inhibiting the function of peroxisome proliferator-activated receptor gamma. However, PGF(2alpha) synthase (PGFS) in adipocytes remains to be identified. Here, we studied the expression of members of the aldo-keto reductase (AKR) 1B family acting as PGFS during adipogenesis of mouse 3T3-L1 cells. AKR1B3 mRNA was expressed in preadipocytes, and its level increased about 4-fold at day 1 after initiation of adipocyte… CONTINUE READING
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