Suppression of abdominal aortic aneurysm formation by inhibition of prolyl hydroxylase domain protein through attenuation of inflammation and extracellular matrix disruption.

Abstract

In the present study we sought to determine the effect of CoCl2, an inhibitor of PHD (prolyl hydroxylase domain protein), on the development of AAA (abdominal aortic aneurysm). AAA was induced in C57BL/6 mice by periaortic application of CaCl2 (AAA group). NaCl (0.9%)-treated mice were used as a sham control (SHAM group). Mice were treated with 0.05% CoCl2… (More)
DOI: 10.1042/CS20130435

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@article{Watanabe2014SuppressionOA, title={Suppression of abdominal aortic aneurysm formation by inhibition of prolyl hydroxylase domain protein through attenuation of inflammation and extracellular matrix disruption.}, author={Aya Watanabe and Toshihiro Ichiki and Chikahiro Sankoda and Yusuke Takahara and Jiro Ikeda and Eriko Inoue and Tomotake Tokunou and Shiro Kitamoto and Kenji Sunagawa}, journal={Clinical science}, year={2014}, volume={126 9}, pages={671-8} }