Suppression of a squamous cell carcinoma (SCC)-related serpin, SCC antigen, inhibits tumor growth with increased intratumor infiltration of natural killer cells.

@article{Suminami2001SuppressionOA,
  title={Suppression of a squamous cell carcinoma (SCC)-related serpin, SCC antigen, inhibits tumor growth with increased intratumor infiltration of natural killer cells.},
  author={Yoshinori Suminami and Shigeki Nagashima and Akihiro Murakami and Shugo Nawata and Toshikazu Gondo and Hiroshi Hirakawa and Fumitaka Numa and Gary A. Silverman and Hiroshi Kato},
  journal={Cancer research},
  year={2001},
  volume={61 5},
  pages={1776-80}
}
Squamous cell carcinoma (SCC) antigen (SCCA), a member of the ovalbumin serine proteinase inhibitor family, serves as a circulating marker of squamous cell carcinoma (SC). One of the SCCAs, SCCA1, has been suggested to play a role in the attenuation of apoptosis in vitro and in the augmentation of tumor growth in vivo. In the present study, the infection of a SCC cell line (SKG IIIa) with recombinant retrovirus that expressed the antisense SCCA mRNA suppressed expression of SCCA in vitro. Local… CONTINUE READING