Suppression of a defective alanyl-tRNA synthetase in Escherichia coli: A compensatory mutation to high alanine affinity

@article{Theall1977SuppressionOA,
  title={Suppression of a defective alanyl-tRNA synthetase in Escherichia coli: A compensatory mutation to high alanine affinity},
  author={Gail Theall and K. B. Low and Dieter S{\"o}ll},
  journal={Molecular and General Genetics MGG},
  year={1977},
  volume={156},
  pages={221-227}
}
Among temperature resistant revertants of a temperature sensitive E. coli alanyl-tRNA synthetase mutant a strain was found which contains an alanyl-tRNA synthetase with an additional mutation in the structural gene of the enzyme. This mutant enzyme has a 9 or 38 fold decreased K m value for alanine compared to that of the thermolabile parental enzyme or to wild-type enzyme, respectively. The alaS gene maps just counterclockwise from recA on the E. coli map (94% cotransduction frequency). It… CONTINUE READING

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