Suppression of Tumor Growth and Angiogenesis by a Specific Antagonist of the Cell-Surface Expressed Nucleolin

@article{Destouches2008SuppressionOT,
  title={Suppression of Tumor Growth and Angiogenesis by a Specific Antagonist of the Cell-Surface Expressed Nucleolin},
  author={Damien Destouches and Diala El Khoury and Yamina Hamma-Kourbali and Bernard Krust and Patricia Albanese and Panagiotis G. Katsoris and Gilles Guichard and J. P. Briand and J. M. Courty and Ara G. Hovanessian},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={1911 - 1922}
}
BACKGROUND Emerging evidences suggest that nucleolin expressed on the cell surface is implicated in growth of tumor cells and angiogenesis. Nucleolin is one of the major proteins of the nucleolus, but it is also expressed on the cell surface where is serves as a binding protein for variety of ligands implicated in cell proliferation, differentiation, adhesion, mitogenesis and angiogenesis. METHODOLOGY/PRINCIPAL FINDINGS By using a specific antagonist that binds the C-terminal tail of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 67 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 48 references

Angiogenesis: an organizing principle for drug discovery?

Nature reviews. Drug discovery • 2007
View 1 Excerpt

Endostatin finds a new partner: nucleolin

J Folkman
Blood • 2007
View 3 Excerpts

Similar Papers

Loading similar papers…