Suppression of Tregs by anti-glucocorticoid induced TNF receptor antibody enhances the antitumor immunity of interferon-α gene therapy for pancreatic cancer

@inproceedings{Aida2014SuppressionOT,
  title={Suppression of Tregs by anti-glucocorticoid induced TNF receptor antibody enhances the antitumor immunity of interferon-α gene therapy for pancreatic cancer},
  author={Kouichirou Aida and Reina Miyakawa and Koji A. O. Suzuki and Kenta Narumi and Takeshi Udagawa and Yuki Yamamoto and T. Chikaraishi and Teruhiko Yoshida and Kazunori Aoki},
  booktitle={Cancer science},
  year={2014}
}
We have reported that interferon (IFN)-α can attack cancer cells by multiple antitumor mechanisms including the induction of direct cancer cell death and the enhancement of an immune response in several pancreatic cancer models. However, an immunotolerant microenvironment in the tumors is often responsible for the failure of the cancer immunotherapy. Here… CONTINUE READING