Suppression of Toll-like receptor 4 activation by caffeic acid phenethyl ester is mediated by interference of LPS binding to MD2.

@article{Kim2013SuppressionOT,
  title={Suppression of Toll-like receptor 4 activation by caffeic acid phenethyl ester is mediated by interference of LPS binding to MD2.},
  author={So Young Kim and Jung Eun Koo and Yun Jee Seo and Nisha Tyagi and Eunshil Jeong and Jaeyoung Choi and Kyung-Min Lim and Zee-Yong Park and Joo Young Lee},
  journal={British journal of pharmacology},
  year={2013},
  volume={168 8},
  pages={1933-45}
}
BACKGROUND AND PURPOSE Toll-like receptors (TLRs) play a crucial role in recognizing invading pathogens and endogenous danger signal to induce immune and inflammatory responses. Since dysregulation of TLRs enhances the risk of immune disorders and chronic inflammatory diseases, modulation of TLR activity by phytochemicals could be useful therapeutically. We investigated the effect of caffeic acid phenethyl ester (CAPE) on TLR-mediated inflammation and the underlying regulatory mechanism… CONTINUE READING
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