Suppression of TH17 Differentiation and Autoimmunity by a Synthetic ROR Ligand

@article{Solt2011SuppressionOT,
  title={Suppression of TH17 Differentiation and Autoimmunity by a Synthetic ROR Ligand},
  author={L. Solt and Naresh Kumar and P. Nuhant and Yongjun Wang and Janelle L Lauer and Jin Liu and M. Istrate and T. Kamenecka and W. Roush and D. Vidovic and S. Sch{\"u}rer and Jihong Xu and Gail Wagoner and P. D. Drew and P. Griffin and T. Burris},
  journal={Nature},
  year={2011},
  volume={472},
  pages={491 - 494}
}
T-helper cells that produce interleukin-17 (TH17 cells) are a recently identified CD4+ T-cell subset with characterized pathological roles in autoimmune diseases. The nuclear receptors retinoic-acid-receptor-related orphan receptors α and γt (RORα and RORγt, respectively) have indispensible roles in the development of this cell type. Here we present SR1001, a high-affinity synthetic ligand—the first in a new class of compound—that is specific to both RORα and RORγt and which inhibits TH17 cell… Expand
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TLDR
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