Suppression of T-lymphocyte activation and chemotaxis by the adenylate cyclase toxin of Bordetella pertussis.

Abstract

The adenylate cyclase toxin (CyaA) released by Bordetella pertussis is an essential virulence factor for colonization of the host. This toxin inhibits migration and activation of phagocytes, thereby preventing bacterial killing. In addition, CyaA interferes with the initiation of adaptive immunity by misdirecting dendritic cell differentiation to a… (More)
DOI: 10.1128/IAI.00200-08

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@article{Paccani2008SuppressionOT, title={Suppression of T-lymphocyte activation and chemotaxis by the adenylate cyclase toxin of Bordetella pertussis.}, author={Silvia Rossi Paccani and Federica Dal Molin and Marisa Benagiano and Daniel Ladant and M M D'Elios and Cesare Montecucco and Cosima Tatiana Baldari}, journal={Infection and immunity}, year={2008}, volume={76 7}, pages={2822-32} }