Suppression of T cell responses by chondromodulin I, a cartilage-derived angiogenesis inhibitory factor: therapeutic potential in rheumatoid arthritis.

@article{Setoguchi2004SuppressionOT,
  title={Suppression of T cell responses by chondromodulin I, a cartilage-derived angiogenesis inhibitory factor: therapeutic potential in rheumatoid arthritis.},
  author={Keigo Setoguchi and Yoshikata Misaki and Kimito Kawahata and Kota Shimada and Takuo Juji and Sakae Tanaka and Hiromi Oda and Chisa Shukunami and Yuriko Nishizaki and Yuji Hiraki and Kazuhiko Yamamoto},
  journal={Arthritis and rheumatism},
  year={2004},
  volume={50 3},
  pages={
          828-39
        }
}
OBJECTIVE Chondromodulin I (ChM-I), a cartilage matrix protein, promotes the growth and proteoglycan synthesis of chondrocytes. However, it also inhibits angiogenesis. Since ChM-I is expressed not only in cartilage, but also in the thymus, we investigated the modulation of T cell function by ChM-I to assess its therapeutic potential in rheumatoid arthritis (RA). METHODS The localization of ChM-I expression in mouse thymus tissue was examined by in situ hybridization. The proliferative… CONTINUE READING
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