Suppression of T-cell functions by human granulocyte arginase.

  title={Suppression of T-cell functions by human granulocyte arginase.},
  author={Markus Munder and Henriette Schneider and Claudia Luckner and Thomas Giese and C. D. Langhans and Jos{\'e} M Fuentes and Pascale Kropf and Ingrid M{\"u}ller and Armin Kolb and Manuel Modolell and Anthony D. Ho},
  volume={108 5},
Chronic inflammation is accompanied by impaired T-cell immunity. In the mouse, myeloid cell-associated arginase accounts for the suppression of immune reactivity in various models of tumor growth and chronic infections. Here we show that arginase I is liberated from human granulocytes, and very high activities accumulate extracellularly during purulent inflammatory reactions. Human granulocyte arginase induces a profound suppression of T-cell proliferation and cytokine synthesis. This T-cell… CONTINUE READING


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