Suppression of T Cell Autophagy Results in Decreased Viability and Function of T Cells Through Accelerated Apoptosis in a Murine Sepsis Model*

@inproceedings{Oami2017SuppressionOT,
  title={Suppression of T Cell Autophagy Results in Decreased Viability and Function of T Cells Through Accelerated Apoptosis in a Murine Sepsis Model*},
  author={Takehiko Oami and Eizo Watanabe and Masahiko Hatano and Satoshi Sunahara and Lisa Fujimura and Akemi Sakamoto and Chizuru Ito and Kiyotaka Toshimori and Shigeto Oda},
  booktitle={Critical care medicine},
  year={2017}
}
OBJECTIVE While type 1 programmed cell death (apoptosis) of T cells leads to immunosuppression in sepsis, a crosstalk between apoptosis and autophagy (type 2 programmed cell death) has not been shown. The aim of this study is to elucidate the details of the interaction between autophagy and immunosuppression. DESIGN Laboratory investigation in the murine sepsis model. SETTING University laboratory. SUBJECTS Six- to 8-week-old male mice. INTERVENTIONS We investigated the kinetics of… CONTINUE READING
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