Suppression of Stat3 promotes neurogenesis in cultured neural stem cells.

  title={Suppression of Stat3 promotes neurogenesis in cultured neural stem cells.},
  author={Feng Gu and Ryuji Hata and Yong-jie Ma and Junya Tanaka and Noriaki Mitsuda and Yoshiaki Kumon and Yasushi Hanakawa and Koji Hashimoto and Koichi Nakajima and Masahiro Sakanaka},
  journal={Journal of neuroscience research},
  volume={81 2},
To investigate the effects of signal transducer and activator of transcription 3 (Stat3) on neural stem cell fate, stem cells were inoculated with an adenovirus vector expressing dominant negative form of Stat3 (Stat3F). One day later, a promoter assay revealed significant reduction of the transcriptional level in the transfected cells. Three days later, Western blot analysis and immunocytochemical analysis revealed that the protein level of microtubule-associated protein (MAP)2 and the number… CONTINUE READING


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