Suppression of Staphylococcal Enterotoxin B-induced Toxicity by a Nuclear Import Inhibitor.

  title={Suppression of Staphylococcal Enterotoxin B-induced Toxicity by a Nuclear Import Inhibitor.},
  author={Danya Liu and Xue Yan Liu and Daniel Robinson and Christie Burnett and Charity Jackson and Louis G Seele and Ruth Ann Veach and Sheila Downs and Robert D. Collins and Dean W. Ballard and Jacek Hawiger},
  journal={The Journal of biological chemistry},
  volume={279 18},
Staphylococcal enterotoxin B and related toxins that target T cells have the capacity to elicit systemic inflammation, tissue injury, and death. Genes that encode mediators of inflammation can be globally inhibited by blocking the nuclear import of stress-responsive transcription factors. Here we show that cell-permeant peptides targeting Rch1/importin alpha/karyopherin alpha 2, a nuclear import adaptor protein, are delivered to T cells where they inhibit the staphylococcal enterotoxin B… CONTINUE READING


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