Suppression of SPIN1-mediated PI3K-Akt pathway by miR-489 increases chemosensitivity in breast cancer.

@article{Chen2016SuppressionOS,
  title={Suppression of SPIN1-mediated PI3K-Akt pathway by miR-489 increases chemosensitivity in breast cancer.},
  author={Xu Chen and Ya-wen Wang and Ai-yan Xing and Shuai Xiang and Duan-bo Shi and Lei Liu and Yan-Xiang Li and P. P. Gao},
  journal={The Journal of pathology},
  year={2016},
  volume={239 4},
  pages={459-72}
}
Drug resistance is one of the major obstacles for improving the prognosis of breast cancer patients. Increasing evidence has linked the association of aberrantly expressed microRNAs (miRNAs) with tumour development and progression as well as chemoresistance. Despite recent advances, there is still little known about the potential role and mechanism of miRNAs in breast cancer chemoresistance. Here we describe that 16 miRNAs were found to be significantly down-regulated and 11 up-regulated in… CONTINUE READING
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