Suppression of SOX7 by DNA methylation and its tumor suppressor function in acute myeloid leukemia.

@article{Man2015SuppressionOS,
  title={Suppression of SOX7 by DNA methylation and its tumor suppressor function in acute myeloid leukemia.},
  author={Cheuk Him Man and Tsz Kan Fung and Haixia Wan and Chae Yin Cher and August Fan and Nelson Ka-Lam Ng and Christa Ho and Thomas Shek-Kong Wan and Toshiyuki Tanaka and Chi Wai Eric So and Yok-lam Kwong and Anskar Y H Leung},
  journal={Blood},
  year={2015},
  volume={125 25},
  pages={
          3928-36
        }
}
SOX7 belongs to the SOX (Sry-related high-mobility group [HMG] box) gene family, a group of transcription factors containing in common a HMG box domain. Its role in hematologic malignancies and, in particular, acute myeloid leukemia (AML) is completely unknown. Here, we showed that SOX7 expression was regulated by DNA hypermethylation in AML but not in acute lymphoblastic leukemia or normal bone marrow cells. In cell lines (KG1, ML2, and K562) and in primary CD34(+) AML samples, SOX7 expression… 
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SOX7 regulates MAPK/ERK-BIM mediated apoptosis in cancer cells
TLDR
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SOX7 promotes the maintenance and proliferation of B cell precursor acute lymphoblastic cells.
TLDR
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SOX7 methylation is an independent prognostic factor in myelodysplastic syndromes.
Long noncoding RNA AB073614 promotes the malignance of glioma by activating Wnt/β-catenin signaling through downregulating SOX7.
TLDR
It is demonstrated that AB073614 promoted the progression of glioma by targeting SOX7 to activate the Wnt/β-catenin signaling pathway, suggesting that the inhibition of AB73614 might be a potential target for therapeutic intervention in gliomas patients.
SOX13 promotes colorectal cancer metastasis by transactivating SNAI2 and c-MET
TLDR
SoX13 is a promising prognostic biomarker in patients with CRC, and blocking the HGF/STAT3/SOX13/c-MET axis with crizotinib could be a new therapeutic strategy to prevent SOX13-mediated CRC metastasis.
MiR-595 targeting regulation of SOX7 expression promoted cell proliferation of human glioblastoma.
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