Suppression of SOX7 by DNA methylation and its tumor suppressor function in acute myeloid leukemia.

@article{Man2015SuppressionOS,
  title={Suppression of SOX7 by DNA methylation and its tumor suppressor function in acute myeloid leukemia.},
  author={Cheuk Him Man and Tsz Kan Fung and Haixia Wan and Chae Yin Cher and August Fan and Nancy F. Ng and Christa Ho and Thomas Shek-Kong Wan and T Tanaka and Chi Wai Eric So and Yok-Lam Kwong and Anskar Yu-Hung Leung},
  journal={Blood},
  year={2015},
  volume={125 25},
  pages={
          3928-36
        }
}
SOX7 belongs to the SOX (Sry-related high-mobility group [HMG] box) gene family, a group of transcription factors containing in common a HMG box domain. Its role in hematologic malignancies and, in particular, acute myeloid leukemia (AML) is completely unknown. Here, we showed that SOX7 expression was regulated by DNA hypermethylation in AML but not in acute lymphoblastic leukemia or normal bone marrow cells. In cell lines (KG1, ML2, and K562) and in primary CD34(+) AML samples, SOX7 expression… CONTINUE READING

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