Suppression of SOCS3 increases susceptibility of renal cell carcinoma to interferon-α.

@article{Tomita2011SuppressionOS,
  title={Suppression of SOCS3 increases susceptibility of renal cell carcinoma to interferon-α.},
  author={Shintaro Tomita and Kei Ishibashi and Koichi Hashimoto and Takashi Sugino and Tomohiko Yanagida and Nobuhiro Kushida and Keiichi Shishido and Ken Aikawa and Yuka Sato and Tatsuo Suzutani and Osamu Yamaguchi},
  journal={Cancer science},
  year={2011},
  volume={102 1},
  pages={57-63}
}
Interferon (IFN)-α is one of the most commonly used agents in immunotherapy for patients with advanced stage renal cell carcinoma. However, because of the drug resistance to IFN-α, its benefits are limited. In this study, we examined whether repression of suppressor of cytokine signaling (SOCS) proteins, which are involved in the IFN-induced signaling pathway, can overcome the IFN resistance of renal cell carcinoma. The effect of IFN-α on SOCS3 expression and cell proliferation was examined… CONTINUE READING
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