Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability.

@article{Holinstat2006SuppressionOR,
  title={Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability.},
  author={Michael Holinstat and Nebojsa M Knezevic and Michael T. Broman and Allen M. Samarel and Asrar B. Malik and Dolly Mehta},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 4},
  pages={2296-305}
}
The interaction of endothelial cells with extracellular matrix proteins at focal adhesions sites contributes to the integrity of vascular endothelial barrier. Although focal adhesion kinase (FAK) activation is required for the recovery of the barrier function after increased endothelial junctional permeability, the basis for the recovery remains unclear. We tested the hypothesis that FAK activates p190RhoGAP and, thus, negatively regulates RhoA activity and promotes endothelial barrier… CONTINUE READING
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