Suppression of PTH by the vitamin D analog eldecalcitol is modulated by its high affinity for the serum vitamin D-binding protein and resistance to metabolism.

@article{Ritter2011SuppressionOP,
  title={Suppression of PTH by the vitamin D analog eldecalcitol is modulated by its high affinity for the serum vitamin D-binding protein and resistance to metabolism.},
  author={Cynthia S. Ritter and Alex J. Brown},
  journal={Journal of cellular biochemistry},
  year={2011},
  volume={112 5},
  pages={1348-52}
}
Eldecalcitol [1α,25-dihydroxy-2β-(3-hydroxypropyloxy)vitamin D(3) ], a vitamin D analog with enhanced efficacy for treatment of osteoporosis, has been found to be less potent than 1,25-dihydroxyvitamin D(3) (calcitriol) in suppressing PTH in vivo. To define the mechanism for the latter observation, we compared the effects of eldecalcitol and calcitriol on PTH secretion by bovine parathyroid cells. While the two compounds showed similar potency when the cells were cultured in medium containing… CONTINUE READING

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