Suppression of PPARβ, and DHA treatment, inhibit NaV1.5 and NHE-1 pro-invasive activities

@article{Wannous2014SuppressionOP,
  title={Suppression of PPARβ, and DHA treatment, inhibit NaV1.5 and NHE-1 pro-invasive activities},
  author={Ramez Wannous and {\'E}meline Bon and Ludovic C. Gillet and Julie Chamouton and G{\"u}nther Weber and Lucie Brisson and Jacques Gor{\'e} and Philippe Bougnoux and Pierre Besson and S{\'e}bastien Roger and St{\'e}phan Chevalier},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2014},
  volume={467},
  pages={1249-1259}
}
Peroxisome proliferator-activated receptor β (PPARβ) and NaV1.5 voltage-gated sodium channels have independently been shown to regulate human breast cancer cell invasiveness. The n-3 polyunsaturated docosahexaenoic acid (DHA, 22:6n-3), a natural ligand of PPAR, is effective in increasing survival and chemotherapy efficacy in breast cancer patient with metastasis. DHA reduces breast cancer cell invasiveness and it also inhibits PPARβ expression. We have shown previously that NaV1.5 promotes MDA… CONTINUE READING

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