Suppression of PMN apoptosis by hypoxia is dependent on Mcl-1 and MAPK activity.

@article{Leuenroth2000SuppressionOP,
  title={Suppression of PMN apoptosis by hypoxia is dependent on Mcl-1 and MAPK activity.},
  author={S J Leuenroth and Patricia S. Grutkoski and Alfred Ayala and H. Hank Simms},
  journal={Surgery},
  year={2000},
  volume={128 2},
  pages={
          171-7
        }
}
BACKGROUND Hypoxia has been shown to delay the onset of neutrophil (polymorphonuclear leukocytes [PMNs]) apoptosis. With the use of antisense oligonucleotides, we have previously demonstrated that Mcl-1 is necessary for this effect. We wanted to further characterize the expression of Mcl-1 and examine signaling pathways required for the delay in apoptosis that is mediated by hypoxia. METHODS For kinase signaling inhibition, PMNs were incubated for 12 hours with the following inhibitors… CONTINUE READING