Suppression of PI3K/Akt signaling by synthetic bichalcone analog TSWU-CD4 induces ER stress- and Bax/Bak-mediated apoptosis of cancer cells

@article{Lin2014SuppressionOP,
  title={Suppression of PI3K/Akt signaling by synthetic bichalcone analog TSWU-CD4 induces ER stress- and Bax/Bak-mediated apoptosis of cancer cells},
  author={Meng-Liang Lin and S Chen and Ren-Yu Huang and Yao-Cheng Lu and Yu-Ren Liao and Mopuru Vijaya Bhaskar Reddy and Chuan-Chun Lee and Tian-Shung Wu},
  journal={Apoptosis},
  year={2014},
  volume={19},
  pages={1637-1653}
}
Suppression of the activity of pro-apoptotic Bcl-2-family proteins frequently confers chemoresistance to many human cancer cells. Using subcellular fractionation, the ER calcium (Ca++) channel inhibitor dantrolene and small interfering RNA (siRNA) against Bax or Bak, we show that the new synthetic bichalcone analog TSWU-CD4 induces apoptosis in human cancer cells by releasing endoplasmic reticulum (ER)-stored Ca++ through ER/mitochondrial oligomerization of Bax/Bak. Blockade of the protein… CONTINUE READING

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