Suppression of NF-κB and IRF-1-induced transcription of the murine IL-12 p40 by transforming growth factor-β Smad pathway in macrophages

In this study, we have characterized the negative regulation of the IL-12 p40 expression by TGF-β in macrophages. Although murine IL-12 p40 promoter contains a putative TGF-β inhibitory element (TIE), neither mutation nor deletion of the TIE had any effect on the inhibitory activity of TGF-β. The NF-κB p65 and interferon regulatory factor (IRF)-1 induced… CONTINUE READING