Suppression of Myc, but not E1a, transformation activity by Max-associated proteins, Mad and Mxi1.

@article{Lahoz1994SuppressionOM,
  title={Suppression of Myc, but not E1a, transformation activity by Max-associated proteins, Mad and Mxi1.},
  author={E. G{\'o}mez Lahoz and Liang-Guo Xu and Nicole Schreiber-Agus and Ronald A. Depinho},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 12},
  pages={5503-7}
}
Mad and Mxi1, two members of the Myc-related basic-region helix-loop-helix/leucine-zipper family of proteins, associate directly with Max to form sequence-specific DNA binding heterodimers that are transactivation-incompetent. Mad-Max complexes have been shown to exert a strong repressive effect on Myc-induced transactivation, perhaps through the competitive occupation of common promoter binding sites also recognized by active Myc-Max heterodimers. To place these recent biochemical observations… CONTINUE READING

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