Suppression of Multidrug Resistance by Migrastatin


Migrastatin (MGS) is a Streptomyces metabolite that inhibits cancer cell migration. In this study, we found that MGS also enhanced the cytotoxicity of vinblastine, vincristine, and taxol in P-glycoprotein-overexpressing VJ-300 cells and P388/VCR cells. Furthermore, MGS increased the intracellular concentration of labeled vinblastine, vincristine, and taxol… (More)
DOI: 10.1038/ja.2006.62


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@article{Takemoto2006SuppressionOM, title={Suppression of Multidrug Resistance by Migrastatin}, author={Yasushi Takemoto and Etsu Tashiro and Masaya Imoto}, journal={The Journal of Antibiotics}, year={2006}, volume={59}, pages={435-438} }