Suppression of MIM by microRNA-182 activates RhoA and promotes breast cancer metastasis

@article{Lei2014SuppressionOM,
  title={Suppression of MIM by microRNA-182 activates RhoA and promotes breast cancer metastasis},
  author={Rong Lei and J Tang and Xiaoyin Zhuang and R. Q. Deng and Gang Li and J Yu and Ye V Liang and J Xiao and Hoau-Yan Wang and Q Yang and Guo-fu Hu},
  journal={Oncogene},
  year={2014},
  volume={33},
  pages={1287-1296}
}
Breast cancer is the most common type of cancer among women worldwide, and metastasis represents the most devastating stage of the disease. Recent studies have revealed that microRNAs (miRNA) have critical roles to regulate cancer cell invasion and metastasis. Here we present evidence to show the role of miR-182 in breast cancer metastasis. miR-182 is upregulated in the malignant cell line variants of both human MCF10 and mouse 4T1 series. Ectopic expression of miR-182 enhanced breast cancer… CONTINUE READING

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