Suppression of MHC class I RNA in highly oncogenic cells occurs at the level of transcription initiation.

The oncogenic potential of some transformed cell lines has been shown in animal tumor models to be the direct result of MHC class I mRNA suppression. Rodent cells established with the highly oncogenic human adenovirus type 12 exhibit greatly reduced levels of class I Ag compared with cells derived with the nononcogenic adenovirus type 5. By using seven… CONTINUE READING