Suppression of MED19 expression by shRNA induces inhibition of cell proliferation and tumorigenesis in human prostate cancer cells.

@article{Cui2011SuppressionOM,
  title={Suppression of MED19 expression by shRNA induces inhibition of cell proliferation and tumorigenesis in human prostate cancer cells.},
  author={Xingang Cui and Danfeng Xu and Chao Lv and Fajun Qu and Jin He and Ming Chen and Yushan Liu and Yi Gao and Jianping Che and Yacheng Yao and Hongyu Yu},
  journal={BMB reports},
  year={2011},
  volume={44 8},
  pages={547-52}
}
MED19 is a member of the Mediator that plays a key role in the activation and repression of signal transduction or the regulation of transcription in carcinomas. To tested the functional role of MED19 in human prostate cancer, we downregulated MED19 expression in prostate cancer cells (PC-3 and DU145) by lentivirus-mediated short hairpin (shRNA), and analyzed the effect of inhibition of MED19 on prostate cancer cell proliferation and tumorigenesis. The in vitro prostate cancer cell… CONTINUE READING

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