Suppression of MDA-MB-435 breast carcinoma cell metastasis following the introduction of human chromosome 11.

@article{Phillips1996SuppressionOM,
  title={Suppression of MDA-MB-435 breast carcinoma cell metastasis following the introduction of human chromosome 11.},
  author={Karen K Phillips and Danny R Welch and Mary E. Miele and Jong Heun Lee and Lisa L. Wei and Bernard E. Weissman},
  journal={Cancer research},
  year={1996},
  volume={56 6},
  pages={1222-7}
}
To determine the relevance of genetic information on chromosome 11 in the development of metastatic breast tumors, we introduced a normal human chromosome 11 into the highly metastatic MDA-MB-435 breast carcinoma cell line via the microcell-mediated chromosome transfer technique. Although the MDA-MB-435 recipient cell line and four randomly selected microcell hybrid clones remained tumorigenic in nude mice, the hybrids were >95% suppressed for metastasis to lung and regional lymph nodes (p<0.01… CONTINUE READING
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