Suppression of Laccase 2 severely impairs cuticle tanning and pathogen resistance during the pupal metamorphosis of Anopheles sinensis (Diptera: Culicidae)

@inproceedings{Du2017SuppressionOL,
  title={Suppression of Laccase 2 severely impairs cuticle tanning and pathogen resistance during the pupal metamorphosis of Anopheles sinensis (Diptera: Culicidae)},
  author={Ming-Hui Du and Zheng-Wen Yan and Y J Hao and Zhen-Tian Yan and Feng-Ling Si and Baiyu Chen and Liang Qiao},
  booktitle={Parasites & Vectors},
  year={2017}
}
BackgroundPhenol oxidases (POs) catalyze the oxidation of dopa and dopamine to melanin, which is crucial for cuticle formation and innate immune maintenance in insects. Although, Laccase 2, a member of the PO family, has been reported to be a requirement for melanin-mediated cuticle tanning in the development stages of some insects, whether it participates in cuticle construction and other physiological processes during the metamorphosis of mosquito pupae is unclear.MethodsThe association… CONTINUE READING
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