Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN.

@article{Takiuchi2014SuppressionOL,
  title={Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN.},
  author={Tsuyoshi Takiuchi and Tomoko Nakagawa and Hironari Tamiya and Hiroaki Fujita and Yoshiyuki Sasaki and Yasushi Saeki and Hiroyuki Takeda and Tatsuya Sawasaki and Alexander Buchberger and Tadashi Kimura and Kazuhiro Iwai},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2014},
  volume={19 3},
  pages={
          254-72
        }
}
Linear ubiquitin chains generated by the linear ubiquitin chain assembly complex (LUBAC) play an important role in NF-κB activation. However, the regulation of linear ubiquitin chain generation by LUBAC is not well characterized. Here, we identified two deubiquitinating enzymes (DUBs), ovarian tumor DUB with linear linkage specificity (OTULIN/Gumby/FAM105B) and cylindromatosis (CYLD) that can cleave linear polyubiquitin chains and interact with LUBAC via the N-terminal PNGase/UBA or UBX (PUB… CONTINUE READING
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