Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival.

@article{Park2004SuppressionOI,
  title={Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival.},
  author={Jung-Hyun Park and Qing Yu and Batu Erman and Jacob S Appelbaum and Diego E. Montoya-Durango and H. Leighton Grimes and Alfred Singer},
  journal={Immunity},
  year={2004},
  volume={21 2},
  pages={289-302}
}
Survival of naive T cells is dependent upon IL-7, which is present in vivo in limiting amounts with the result that naive T cells must compete for IL-7-mediated survival signals. It would seem imperative during T cell homeostasis that limiting IL-7 be shared by the greatest possible number of T cells. We now describe a novel regulatory mechanism that specifically suppresses IL7Ralpha transcription in response to IL-7 and other prosurvival cytokines (IL-2, IL-4, IL-6, and IL-15). Consequently… CONTINUE READING
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