Suppression of IL-22-producing T helper 22 cells by RPE cells via PD-L1/PD-1 interactions.

Abstract

PURPOSE To determine whether RPE cells can suppress a novel T helper subset, the Th22 cells, via costimulatory interactions. METHODS Primary RPE cells were established from normal C57BL/6 mice. The target CD4(+) Th22 cells from spleen cells in wild-type control or knockout donors were used. T cell activation was assessed by examining BrdU incorporation… (More)
DOI: 10.1167/iovs.13-12703

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