Suppression of IL‐2 Production and Proliferation of CD4+ T Cells by Tuberostemonine O

  title={Suppression of IL‐2 Production and Proliferation of CD4+ T Cells by Tuberostemonine O},
  author={Eun Jung Jang and Yun‐Seo Kil and Hye Ryeon Park and Sera Oh and Hyo Kyeong Kim and Mi Gyeong Jeong and Eun Kyoung Seo and Eun Sook Hwang},
  journal={Chemistry \& Biodiversity},
Tuberostemonine stereoisomers are natural alkaloids found in Stemona tuberosa, that are known to have anti‐inflammatory and anti‐infective properties. Tuberostemonine alkaloids inhibit inflammation by suppressing the expression of inflammatory mediators such as cyclooxygenase and nitric oxide synthase. However, the direct immunomodulatory properties of tuberostemonine alkaloids in T cells have not been elucidated so far. In this study, the activities in T cells of tuberostemonine N (TbN) and a… Expand
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