Suppression of Homologous Recombination by insulin-like growth factor-1 inhibition sensitizes cancer cells to PARP inhibitors

@inproceedings{Amin2015SuppressionOH,
  title={Suppression of Homologous Recombination by insulin-like growth factor-1 inhibition sensitizes cancer cells to PARP inhibitors},
  author={Oreekha Amin and M Beauchamp and Paul Abou Nader and Ido Laskov and Sanaa Iqbal and Cooke Philip and Amber Yasmeen and Walter Henri Gotlieb},
  booktitle={BMC Cancer},
  year={2015}
}
BackgroundImpairment of homologous recombination (HR) is found in close to 50 % of ovarian and breast cancer. Tumors with BRCA1 mutations show increased expression of the Insulin-like growth factor type 1 receptor (IGF-1R). We previously have shown that inhibition of IGF-1R results in growth inhibition and apoptosis of ovarian tumor cells. In the current study, we aimed to investigate the correlation between HR and sensitivity to IGF-1R inhibition. Further, we hypothesized that IGF-1R… CONTINUE READING
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